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<p class=MsoNormal><span style='color:black'>Dear All,<o:p></o:p></span></p>
<p class=MsoNormal><span style='color:black'><o:p> </o:p></span></p>
<p class=MsoPlainText><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";
color:black'>This is a kind reminder that our next LI-LA-SiGMA seminar is
today, April </span><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";
color:black'>26</span><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";
color:black'> at 2.00pm. Our speaker is </span><span style='font-size:11.0pt;
font-family:"Calibri","sans-serif";color:black'>Dr. Jake Chen, Indiana
University - Purdue University Indianapolis (IUPUI)</span><u><span
style='font-size:11.0pt;font-family:"Calibri","sans-serif"'><o:p></o:p></span></u></p>
<p class=MsoPlainText><span style='font-size:11.0pt;font-family:"Calibri","sans-serif";
color:black'><o:p> </o:p></span></p>
<p class=MsoPlainText style='text-align:justify'><b><span style='font-size:
11.0pt;font-family:"Calibri","sans-serif";color:black'>Title: </span></b><b><span
style='font-size:11.0pt;font-family:"Calibri","sans-serif"'>3D+ X-ray &
Neutron Imaging in Materials Science for Energy: Hydrogen Storage and Batteries<span
style='color:black'><o:p></o:p></span></span></b></p>
<p class=MsoPlainText style='text-align:justify'><span style='font-size:11.0pt;
font-family:"Calibri","sans-serif";color:black'><o:p> </o:p></span></p>
<p class=MsoNormal style='text-align:justify'><u>Abstract:</u> <span
style='color:black'>Today, the default model for small molecule drug discovery
is to screen libraries of chemical compounds against a single protein drug
target determined to be critical to a disease. The process is long, costly,
serendipitous, and infested with failures. New evidence from emerging genome
biology studies suggests that complex diseases may never be addressed by simple
“one disease one target” or “target-compound docking” models. New translational
medicine approaches are needed to save future pharmaceutical industry from
crumbling.<o:p></o:p></span></p>
<p class=MsoNormal style='text-align:justify'><span style='color:black'>In this
talk, I describe how advances in translational bioinformatics are making it
possible to begin approaching such drug discovery challenges with new
computational ideas. I will introduce the concept of connectivity maps, and
then describe how bioinformatics techniques can be developed to study the
complex relationships among diseases, genes, and drugs. I will show how
converging techniques, software tools, and databases are being developed in our
research program at the Indiana Center for Systems Biology and Personalized
Medicine and my lab (</span><a href="http://bio.informatics.iupui.edu/"><span
style='color:black'>http://bio.informatics.iupui.edu/</span></a><span
style='color:black'>) to achieve progress towards a new paradigm of
computational drug discovery.<o:p></o:p></span></p>
<p class=MsoNormal style='text-align:justify'><u><o:p><span style='text-decoration:
none'> </span></o:p></u></p>
<p class=MsoNormal style='text-align:justify'><u>Bio:</u> Dr. Jake Chen is an
associate professor with tenure at Indiana University School of Informatics and
Purdue University Department of Computer and Information Science in
Indianapolis (IUPUI). He is the founding director of the Indiana Center for
Systems Biology and Personalized Medicine, a member of the Indiana University
Simon Cancer Center, and a member of the Center for Computational Biology and
Bioinformatics at Indiana University School of Medicine. He is also an ACM
senior member, IEEE senior member, and chair of the IEEE Engineering in Biology
and Medicine Society Central Indiana Chapter. He currently serves on the
editorial boards of several international bioinformatics journals including BMC
Systems Biology, organized over 100 Academic meetings in informatics and
computer science, and served on many research panels or committees<a
name="_GoBack"></a> for NIH, NSF, DOE, and the National Academies. He is the
recipient of the Canary Foundation 2008 Bioinformatics Dissemination Award, a <span
style='layout-grid-mode:line'>Translational Research into Practice (TRIP)
scholar at Indiana University, </span>and a 2010 Cambridge Health Institute’s<span
style='layout-grid-mode:line'> Translational Medicine Conference Distinguished
Faculty</span>. He holds masters and doctoral degrees in Computer Science &
Engineering from the University of Minnesota and a bachelor degree in
Biochemistry & Molecular Biology from Peking University of China.<o:p></o:p></p>
<p class=MsoNormal style='text-align:justify'>His research expertise spans over
biological data management, biological data mining, bioinformatics, systems
biology, and clinical applications of genomics in predictive and personalized
medicine, with more than 90 research publication—including three edited books, <i>Biological
Database Modeling</i>, <i>Biological Data Mining</i>, and <i>Translational
Bioinformatics</i> (forthcoming)—and more than 100 invited talks worldwide. <o:p></o:p></p>
<p class=MsoNormal style='text-align:justify'>He also has considerable
experience in leading Informatics R&D projects in the biopharmaceutical
industry. Prior to joining Academia in 2004, he helped design commercial
GeneChip microarray products for human, mouse, and rat at Affymetrix, Inc., San
Jose, California and led a team to data mine the world’s first comprehensive
human protein interactome collected at Myriad Proteomics, Inc., Salt Lake City,
Utah. In Indiana, he co-founded the non-profit Indiana Biomedical Entrepreneur’s
Network (IBEN) to promote biotechnology commercialization efforts and two
biotech startup businesses to promote predictive and personalized medicine
practices. <o:p></o:p></p>
<p class=MsoNormal style='text-align:justify;text-autospace:none'><span
style='color:#1F497D'><o:p> </o:p></span></p>
<p class=MsoPlainText><span style='font-size:11.0pt;font-family:"Calibri","sans-serif"'>The
access grid locations are as follow: <o:p></o:p></span></p>
<p class=MsoPlainText><span style='font-size:11.0pt;font-family:"Calibri","sans-serif"'><o:p> </o:p></span></p>
<p class=MsoNoSpacing style='line-height:115%'><u>Tulane:</u> AG room: 403
Stanley Thomas Hall<o:p></o:p></p>
<p class=MsoNoSpacing style='line-height:115%'><u>University of Louisiana at
Lafayette</u>: AG room: Abdalla Hall<o:p></o:p></p>
<p class=MsoNoSpacing style='line-height:115%'><u>Southern University:</u>
AG room: 218 Moore Hall<o:p></o:p></p>
<p class=MsoNoSpacing style='line-height:115%'><u>UNO:</u> AG room: <span
style='color:black'>SC 2002</span><o:p></o:p></p>
<p class=MsoNoSpacing style='line-height:115%'><u>LSU:</u> AG room:
Johnston 338<o:p></o:p></p>
<p class=MsoNoSpacing style='line-height:115%'><u>LATECH:</u> AG room: 234
Netken Hall<o:p></o:p></p>
<p class=MsoPlainText style='text-align:justify'><span style='font-size:11.0pt;
font-family:"Calibri","sans-serif"'><o:p> </o:p></span></p>
<p class=MsoPlainText style='text-align:justify'><span style='font-size:11.0pt;
font-family:"Calibri","sans-serif"'>Please, distribute this email to your
students and colleagues.<o:p></o:p></span></p>
<p class=MsoNormal><o:p> </o:p></p>
<p class=MsoNormal>Kind Regards,<o:p></o:p></p>
<p class=MsoNormal>Dentcho<o:p></o:p></p>
<p class=MsoNormal><o:p> </o:p></p>
<p class=MsoNormal>----<o:p></o:p></p>
<p class=MsoNormal>Dentcho A. Genov, PhD<o:p></o:p></p>
<p class=MsoNormal>The LONI Institute Fellow<o:p></o:p></p>
<p class=MsoNormal>Assistant Professor of Physics & Electrical Engineering<o:p></o:p></p>
<p class=MsoNormal>Louisiana Tech University, Engineering Annex, Room 220<o:p></o:p></p>
<p class=MsoNormal>599 W Arizona Ave, Ruston LA 71272<o:p></o:p></p>
<p class=MsoNormal><o:p> </o:p></p>
<p class=MsoNormal>Phone: (318) 257-4190, Fax: (318) 257-2777<o:p></o:p></p>
<p class=MsoNormal>Webpage: http://www.phys.latech.edu/~dgenov/<o:p></o:p></p>
<p class=MsoNormal><o:p> </o:p></p>
<p class=MsoNormal><o:p> </o:p></p>
<p class=MsoNormal><o:p> </o:p></p>
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